MYB activation and other genomic alterations in adenoid cystic carcinoma NAHNPS Companion Meeting, USCAP 2013 Annual Meeting
نویسنده
چکیده
Adenoid cystic carcinoma (ACC) is a relatively uncommon tumor, with a reported incidence of 4.5 cases per million individuals . The age range for diagnosis is wide, with tumors arising at almost equal incidence in any decade of adulthood. The salivary and lacrimal glands are among the most common sites at which this tumor arises. It is the most common malignancy to arise in the minor salivary glands, and is also one of the most common cancers of the parotid and sublingual salivary glands . ACC also arises in glandular tissue of the nasal passages and tracheobronchial tree. ACC arises less frequently in sites outside of the head and neck, including the breast and vulva.
منابع مشابه
Mutation signature of adenoid cystic carcinoma: evidence for transcriptional and epigenetic reprogramming.
Adenoid cystic carcinoma (ACC), a relatively rare malignancy usually of salivary gland origin, has a signature v-myb avian myeloblastosis viral oncogene homolog-nuclear factor I/B (MYB-NFIB) gene fusion that activates MYB transcriptional regulatory activity. A new study in this issue by Stephens et al. is a comprehensive genomic mutation profiling analysis of this neoplasm and documents a commo...
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Adenoid cystic carcinoma (ACC), the second most common salivary gland malignancy, is notorious for poor prognosis, which reflects the propensity of ACC to progress to clinically advanced metastatic disease. Due to high long-term mortality and lack of effective systemic treatment, the slow-growing but aggressive ACC poses a particular challenge in head and neck oncology. Despite the advancements...
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BACKGROUND Adenoid cystic carcinoma (ACC) is a rare tumor of secretory glands. In this study, recent advances in molecular characterization and in therapeutics are reviewed. METHODS A search of articles in PubMed and of abstracts from national meetings was performed regarding ACC. RESULTS Recent genetic analyses found that recurrent chromosome 6:9 translocations in ACC generate an MYB:NFIB ...
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